Expression Difference of IncRNAs in Left Atrial Appendage in Rheumatic Valve Disease Patients with Atrial Fibrillation and in Patients with Sinus Rhythm
TAN Hongwei
LI Jinping
XIONG Qi
NIE Yongmei
LIAO Bing
YU Fengxu
Abstract：Objective:To explore the expression difference of Iong non-coding RNA(IncRNAs)in Left atrial appendage of patients with rheumatic valvular heart disease complicated with chronic atrial fibrillation and sinus rhythm.Methods:Three patients with rheumatic heart valvular atrial fibrillation and rheumatic heart disease with sinus rhythm were selected.A small amount of left atrial appendage tissue was taken during the operation and passed high-throughput second-generation sequencing,Gene Otology enrichment analysis,Kyoto Encyclopedia of Genes and Genomes Pathway significant enrichment analysis analyzed the biological function of IncRNAs target genes,and infers the role of IncRNAs.Results:A total of 38 IncRNAs were different between the atrial fibrillation group and the sinus group(P＜0.05),with 15 up-regulated expressions and 23 down-regulated expressions.There were 1 475 mRNAs in atrial fibrillation group were significantly different from the sinus group(P＜0.05),with 635 up-regulated expressions and 840 down-regulated expressions.Conclusion:Differentially expressed IncRNAs related to atrial fibrillation in rheumatic valvular heart disease may be related to atrial fibrillation electrical remodeling and abnormal calcium processing mechanisms.They may be related to metabolic pathways,myocardial contraction,cardiomyocyte adrenergic signaling,and mitogen-activated protein kinase(MAPK)signaling pathway,cyclic guanosine phosphate(cGMP)-protein kinase G(PKG)signaling pathway,and calcium signal pathway.
Keywords：atrial fibrillationrheumatic heart valve diseasesinus rhythmlong non-coding RNAleft atrial appendage
Publication Date：2024-06-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 1941-1950 )