Clinical Research of Boost Qi and Invigorate Blood Decoction Combined with Sacubitril Valsartan for the Treatment of Heart Failure with Dilated Cardiomyopathy
TANG Wei
CHANG Peifen
LIU Bo
LI Tianli
WANG Jing
WANG Mingming
Abstract：Objective:To observe the effects of boost Qi and invigorate blood decoction combined with sakubactril valsartan on clinical symptoms and ventricular remodeling in heart failure with dilated cardiomyopathy(DCM).Methods:Ninety-nine patients of heart failure with DCM from January 2020 to January 2023 were randomly divided into the control group(49 cases,treating with sakubactril valsartan)and observation group(50 cases,treating with boost Qi and invigorate blood decoction on the basis of sakubactril valsartan).The clinical efficacy of the two groups,Chinese medicine symptom score,cardiac displacement index[cardiac output(CO),cardiac index(CI),left ventricular ejection time(LVET),left ventricular work index(LCWi),peripheral resistance(SVR)],ventricular remodeling index[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)],serum type B natriuretic peptide(NT-proBNP),hypersensitive C-reactive protein(hs-CRP),cardiac troponin I(cTnI)were compared between two groups before and after treatment.Results:The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(88.00%and 71.43%,P<0.05).After treatment,the scores of TCM symptoms,SVR,LVESD,LVEDD,NT-proBNP and hs-CRP in both groups decreased than those before treatment(P<0.05),CO,CI,LVET,LCWi and LVEF increased more than those before treatment,and the differences were statistically significant(P<0.05).Conclusion:Boost Qi and invigorate blood decoction combined with sakubactril valsartan for treating heart failure with DCM could improve clinical symptoms,cardiac function and ventricular remodeling,with high safety.
Keywords：dilated cardiomyopathyheart failureboost Qi and invigorate blood decoctionsacubitril valsartanventricular remodeling
Publication Date：2024-05-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1756-1760 )