Systematic Evaluation of the Effect and Safety of Xiongshao Capsules for the Treatment of Coronary Heart Disease Angina Pectoris
ZHANG Miao
XU Guipeng
CHEN Lijie
LIN Baohong
WU Zhengzhi
Abstract：Objective:To evaluate the clinical effect and safety of Xiongshao Capsules for the treatment of coronary heart disease angina pectoris.Methods:Web of SCI,PubMed,EMbase,the Cochrane Library,WanFang data Resource System(WanFang Database),VIP Chinese Science and Technology Journal Full-text Database(VIP),CNKI,China Biomedical Literature Service System(SinoMed)and other databases were searched.The randomized controlled trials(RCT)of Xiongshao Capsules compared with conventional Western medicine or Xuefu Zhuyu Capsules intervention in the treatment of coronary heart disease angina pectoris were included.Two reviewers independently screened and extracted literature data to assess the risk of bias.RevMan 5.3 software was used for Meta-analysis.Result:A total of 12 literatures were included,including 1309 patients.Meta-analysis results showed that the experimental group the total clinical efficacy(RR=1.17,95%CI 1.11-1.23,P<0.00001),electrocardiogram effect(RR=1.22,95%CI 1.09-1.36,P =0.0003),and lipid triacylglycerol(TG)(MD=-0.19,95%CI-0.35--0.04,P =0.02)reduced and High density lipoprotein cholesterol(HDL-C)(MD=0.13,95%CI 0.07-0.19,P<0.0001)were better than that of control group.There was no significant difference in TC,LDL-C and adverse reactions between two groups(P>0.05).Conclusion:The current evidence showed that Xiongshao Capsules for the treatment of coronary heart disease angina pectoris with clear effect and better safety.
Keywords：coronary heart diseaseangina pectorisXiongshao Capsulesactivating blood circulation and removing blood stasissystematic evaluation
Publication Date：2024-04-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 1354-1362,1394 )