Randomized Controlled Trials of Traditional Chinese Medicine Treatment for Amnestic Mild Cognitive Impairment
DU Yida
LI Chengfu
HE Chunying
CHEN Zhiyan
CHEN Wenjie
ZHAN Min
HU Xiaohua
LI Yutong
SUN Linjuan
ZHENG Xiaoying
Abstract：Objective:To evaluate the current status of randomized controlled trials for the treatment of amnestic mild cognitive impairment,and to provide a basis for future core index set research.Methods:Seven databases including CNKI,WanFang Data,VIP,PubMed,EMbase,and the Cochrane Library were searched to collect randomized controlled trials of traditional Chinese medicine(TCM)treatment for amnestic mild cognitive impairment.The literature was independently screened and data were extracted by two evaluators according to pre-established inclusion and exclusion criteria.Additionally,the utilization of outcome indicators in the included randomized controlled trials was described.Results:A total of 26 efficacy indicators were utilized in the 23 articles,and the top 5 therapeutic indexes were as follows:18(78.3％)on the Mini-Mental State Examination(MMSE),14(60.9％)on the Montreal Cognitive Assessment Scale(MoCA),14(60.9％)on the TCM Syndrome Score Scale,10(43.5％)on the Activities of Daily Living Scale(ADL),and 6(26.1％)on clinical efficacy.The follow-up time within 3 months was observed in seventy-eight percent of the studies.Conclusion:The randomized controlled trials of TCM treatment for amnestic mild cognitive impairment showed significant heterogeneity in the selection,measurement,and reporting of outcome indicators,so the core index set should be studied,and the evaluation system of randomized controlled trials should be established and improved.
Keywords：amnestic mild cognitive impairmenttraditional Chinese medicinerandomized controlled trialsoutcome index
Publication Date：2024-03-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1011-1015 )