Mechanism of the "Same Treatment of Different Diseases" of Salvia Miltiorrhiza for Treating Coronary Heart Disease and Stroke Based on Network Pharmacology and Molecular Docking
CAO Weiyi
FU Jinyi
LI Rui
CHENG Miaomiao
Abstract：Objective:To explore the heteropathy mechanism and key therapeutic targets of the"same treatment for different diseases"of salvia miltiorrhiza for the treatment of coronary heart disease(CHD)and stroke by network pharmacology and molecular docking.Methods:Potential targets for the treatment of coronary heart disease and stroke were screened through traditional Chinese medicine(TCM)System Pharmacology Database and Analysis Platform(TCMSP),online human Mendelian Genetic database(OMIM),DrugBank,and other databases.Target protein-protein interaction(PPI),Gene ontology(GO)and Kyoto Genome Encyclopedia(KEGG)pathway analysis via the Metascape online platform.The active ingredient-key target-core pathway network was constructed using Cytoscape 3.9.1 to screen out the core components.Molecular docking was used to simulate the degree of binding between core components and key targets.Results:Fifty-two potential targets of salvia miltiorrhea for the treatment of coronary heart disease and stroke were selected,mainly concentrated in the pathways of advanced glycation end products(AGE)/receptor for advanced glycation end products(RAGE),platelet activation,lipid and atherosclerosis,fluid shear stress and atherosclerosis.The core pharmacodynamic components stably bound to phosphatidylinositol-3-kinase(PI3K),protein kinase B(AKT),nitric oxide synthase(NOS3,eNOS),B lymphocytoma-associated protein-2(Bcl-2),cyclooxygenase 2(PTGS2),integrin subunit α2b(ITGA2B),matrix metalloproteinase 9(MMP9),and other targets.Conclusion:The"same treatment for different diseases"of salvia miltiorrhoea can improve atherosclerosis in coronary heart disease and stroke mainly through anti-platelet activation and aggregation,protection of cardiovascular and cerebrovascular cells,stabilization of plaque,and reduction of inflammation,with potential target competition and synergistic effects.
Keywords：coronary heart diseasestrokesalvia miltiorrhizanetwork pharmacology
Publication Date：2024-02-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 582-584,586-590 )