Clinical Effect of Chinese Herbal Compound Combined with Nicorandil for the Treatment of Microvascular Angina:a Meta-analysis and Trial Sequential Analysis
ZHOU Lijun
YANG Luoqi
YU Linbo
XIE Liandi
Abstract：Objective:To systematically evaluate the efficacy and safety of Chinese herbal compound with nicorandil for the treatment of microvascular angina.Methods:The randomized controlled trials of Chinese herbal compound with nicorandil in the treatment of microvascular angina were searched in the CNKI,WanFang,VIP,China Biomedical Literature Database,PubMed,the Cochrane Library,EMbase,and other databases from the establishment of the database to September 2022.Literature screening,data extraction,and quality assessment were conducted independently by two researchers,RevMan 5.4 and TSA 0.9Beta software were used for Meta-analysis and sequential analysis.Results:A total of 13 literatures were included,including 1 134 patients.The results of Meta-analysis showed that compared with the control group,the clinical efficacy(RR=1.23,95%CI 1.15-1.31,P<0.00001)was better in the treatment group,the frequency of angina attacks(SMD=-2.51,95%CI-3.51--1.52,P<0.00001)and duration(SMD=-1.10,95%CI-1.36--0.85,P<0.00001)decreased,serum nitric oxide concentration(SMD=2.53,95%CI 1.77-3.30,P<0.000 01)increased,endothelin-1(SMD=-1.89,95%CI-2.09--1.70,P<0.000 01),hypersensitive C-reactive protein(MD=-2.38,95%CI-2.72--2.03,P<0.000 01),interleukin-1(MD=-33.81,95%CI-46.65--20.97,P<0.000 01)and interleukin-6(SMD=-5.20,95%CI-5.89--4.51,P<0.000 01)decreased,without increasing adverse drug reactions(RR= 0.88,95%CI 0.26-3.01,P =0.84),with a certain degree of safety.Conclusion:The current evidence suggested that Chinese herbal compound with nicorandil in the treatment of microvascular angina showed better clinical efficacy and definite safety had better clinical efficacy and safety.
Keywords：microvascular anginaChinese herbal compoundnicorandilclinical efficacyMeta-analysistrial sequential analysis
Publication Date：2023-12-16
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 4475-4482 )