Clinical Efficacy of Cooling Blood and Promoting Blood Stasis Method in the Treatment of Ischemic Stroke with Stasis-heat Interconnection
HE Xiaogang
ZHANG Rong
KAN Lijuan
ZHANG Yi
CAI Qiufang
XU Chunyang
Abstract：Objective:To explore the effect and mechanism of the method of cooling blood and promoting blood stasis in the treatment of apoplexy with stasis and heat.Methods:A total of 100 patients with ischemic stroke syndrome of stasis and heat interjunction were divided into western medicine group and combined group according to random envelope method,with 50 cases of each group.The western medicine group was given the conventional western medicine,and the combined group was given the treatment of cooling blood and promoting blood stasis based on the theory of brain-gut linkage.The efficacy,safety,and scores of National Institutes of Health Stroke Scale(NIHSS),Activities of Daily Living(ADL)scale,gastrointestinal dysfunction score,gastrointestinal symptom score,before and after 14 days of treatment were compared between two groups.The relationship between gastrointestinal function and brain-gut peptide(CCK-8),nuclear factor-κB(NF-κB),interleukin-1(IL-1),tumor necrosis factor-α(TNF-α),the relationship between CCK-8 and NF-κB,IL-1 and TNF-α,and the relationship between CCK-8 and NIHSS score were analyzed by Pearson.Results:After 14 days of treatment,the total effective rate of the combination group was 96.00%,which was higher than that of the western medicine group(84.00%)(P＜0.05).After treatment,the NIHSS score in combination group was lower than that of the western medicine group,ADL score was higher than that of the western medicine group(P＜0.01).After treatment,the gastrointestinal dysfunction score and gastrointestinal symptoms score in combination group were lower than those in the western medicine group(P＜0.001).After treatment,CCK-8,NF-κB,IL-1,and TNF-αin combination group were lower than those in the western group(P＜0.001).There was no significant difference in the incidence of adverse reactions between the combined group(2.00%)and the western group(4.00%)(P＞0.05).Gastrointestinal dysfunction score and gastrointestinal symptom score were positively correlated with CCK-8,NF-κB,IL-1,and TNF-α at the corresponding time point before treatment and after treatment(P＜0.001).CCK-8 was positively correlated with NF-κB,IL-1 and TNF-α at the corresponding time point before treatment and after treatment(P＜0.001).CCK-8,NF-κB,IL-1,TNF-αwere positively correlated with the NIHSS score at the corresponding time point before treatment and after treatment(P＜0.001).Conclusion:Based on the theory of brain-gut linkage,the method of cooling blood and promoting blood stasis in the treatment of stroke syndrome of stasis and heat interjunction can improve gastrointestinal function,regulate the CCK-8/NF-κB/IL-1 signaling pathway of brain-gut axis,play the role of anti-inflammatory and reduce nerve function deficit,thus enhancing the curative effect and improving the patients'ability of daily life.
Keywords：strokebrain-gut linkage theorymethod of cooling blood and promoting blood stasisstasis and heatgastrointestinal functionbrain-gut peptidenuclear factor-κBinterleukin-1
Publication Date：2023-12-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 4416-4420 )