Relationship between Serum Eosinophils and High-sensitivity C-reactive Protein and Coronary Lesions and Prognosis
ZHANG Junqi
REN Yunxia
FAN Chunyu
Abstract：Objective To investigate the relationship between serum eosinophils(EOS)and high-sensitivity C-reactive protein(hs- CRP)levels and coronary artery lesions and prognosis in patients with coronary artery disease(CHD).Methods 111 patients with CHD admitted to the Department of Cardiology,the First Hospital of Shanxi Medical University from May 2016 to October 2016 were selected as the observation group,and 66 patients without CHD were as the control group.The patients in the observation group were divided into acute myocardial infarction(AMI)group,unstable angina(UA)group and stable angina pectoris(SAP)group.The serum EOS and hs-CRP levels were compared between the two groups.According to the degree of coronary artery stenosis and the number of lesions involved,the relationship between serum EOS and hs-CRP levels,and the degree and number of coronary lesions were analyzed.The patients were followed up to record the occurrence of major cardiovascular events(MACE).Results The serum EOS level in the CHD group was lower than that in the control group,and the hs-CRP level was significantly higher than that in the control group(P <0.05).There was a significant negative correlation between EOS level and hs-CRP(r=-0.3,P <0.01).The serum EOS level in the severe coronary artery stenosis group was lower than that in the mild stenosis group(P <0.05).The hs-CRP level in the severe and moderate stenosis group was significantly higher than that in the mild stenosis group(P <0.05).The hs-CRP level was positively correlated with the degree of stenosis(r=0.345,P <0.01).There was no significant difference in serum EOS and hs-CRP levels among different number of coronary artery lesions(P >0.05).Multivariate logistic regression analysis showed that hs -CRP,cardiac troponin I(cTnI),and N-terminal pro-brain natriuretic peptide(NT-proBNP)were risk factors for recent MACE. Conclusion There is a significant negative correlation between serum EOS and hs-CRP in patients with CHD.The higher the hs- CRP level,the more severe the coronary lesions.The hs-CRP has a predictive value for the short-term prognosis in patients with CHD.
Keywords：coronary heart diseasecoronary artery lesionseosinophilshigh-sensitivity C-reactive proteinprognosiscorrelation
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 243-246 )