Expressions of CASC2 and miRNA-21 in Peripheral Blood of Patients with ST-elevation Acute Myocardial Infarction Undergoing Emergency Percutaneous Coronary Intervention
MENG Qingguo
BIE Zidong
REN Faxin
Abstract：Objective To analyze the expressions of long non-coding RNA cancer susceptibility candidate 2(CASC2)and microRNA-21 (miRNA-21)in peripheral blood of patients with ST-elevation acute myocardial infarction(STEAMI)undergoing emergency percutaneous coronary intervention(PCI),and to investigate the clinical value of CASC2 and miRNA-21 in STEAMI.Methods From December 2016 to May 2017,55 patients with STEAMI who underwent emergency PCI in the Department of Cardiology of Weihai Central Hospital affiliated to Qingdao University were selected as STEAMI group,and32 healthy subjects without STEAMI were included in the control group.The patients in STEAMI group were divided into myocardial ischemia-reperfusion injury(MIRI)group(13 cases)and non-MIRI group(42 cases)according to whether or not MIRI occurred after PCI.The expressions of peripheral CASC2and miRNA- 21 were detected by real-time fluorescence quantitative polymerase chain reaction.The correlation between CASC2,miRNA-21, and cardiac troponin T(cTnT)and high sensitive C reactive protein(hs-CRP)was analyzed.Results The expressions of CASC2 and miRNA-21 in STEAMI group before and after PCI were significantly higher than those in control group(P <0.05).The expressions of CASC2 and miRNA-21in MIRI group were lower than non-MIRI group(P <0.05).The expressions of CASC2,miRNA-21, and cTnT were significantly correlated in patients with STEAMI after PCI(r=0.35,P =0.04;r=0.45,P =0.03),and had no correlation with hs-CRP(r=0.12,P =0.32;r=0.22,P =0.45).There was a positive correlation between CASC2 and miRNA-21in patients with STEAMI after PCI(r=0.33,P =0.04).Conclusion CASC2 and miRNA-21 may be involved in the process of MIRI in STEAMI.CASC2 and miRNA-21 can predict MIRI.
Keywords：ST-elevation acute myocardial infarctionpercutaneous coronary interventionlong non-coding RNAsmicroRNA-21cancer susceptibility candidate 2
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 176-179 )