Network Pharmacological Research on Material Basis and Mechanism of Japanese Fleeceflower in Anti-atherosclerosis
JU Jianqing
LAI Runmin
LIN Qian
SHANG Qinghua
XU Hao
Abstract：Objective To explore the material basis and underlying molecular mechanism of Japanese Fleeceflower, a Chinese herb for acti-vating blood circulation and detoxicating, in treating atherosclerosis (AS).Methods Based on network pharmacology, Bioinformatics A-nalysis Tool for Molecular mechanism of Traditional Chinese Medicine (BATMAN-TCM) was used to filtrate active components and po-tential target genes of Japanese Fleeceflower.PALM-IST was used to perform literature mining from PubMed database to gain targetgenes of AS and Cytoscape 3.2.1 software was used to build the"component-target"network of Japanese Fleeceflower in treating AS andto analyze its topological structure.Gene enrichment analysis was carried out using FunRich 3.1.3 software.Results Twenty-one activecomponents of Japanese Fleeceflower were acquired, mainly consisted of resveratrol, trans-resveratrol, Rheum anthraquinones and organicacids.One hundred and sixty target genes were found and the important target genes were PTGS2, PTGS1, PGR, ESR1, ALOX5, VDR, SOX9 and MED1.Japanese Fleeceflower found to be involved in 4 biological processes including signal transduction, cell communication, energy pathway and metabolism, and 18 signaling pathways.Regulating on Toll-like receptors (TLRs), RARs and downstream signaltransduction systems was the main potential mechanisms of Japanese Fleeceflower in anti-atherosclerosis treatment.Conclusion The re-sults preliminarily demonstrate the multi-component, multi-target and multi-pathway effects of Japanese Fleeceflower in anti-atherosclero-sis, and provide the basis for further pharmacological research.
Keywords：atherosclerosisJapanese Fleecefloweractivating blood circulation and detoxicatingnetwork pharmacologymolecular mecha-nism
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 15-20 )