Clinical Observation on Yinxin Tongzhi Tablet in the Treatment of Vascular Cognitive Impairment with Non-Dementia
Jiang Wenfei
Liao Weilong
Zhu Guoqin
Gao Penglin
Yuan Yike
Pan Weidong
Abstract：Objective To investigate the effect of Yinxin Tongzhi tablet (YTT) in the treatment of vascular cognitive impairment with non-de-mentia (VCIND). Methods Sixty-eight patients with VCIND two groups:control group treated with placebo,and treatment group ( n=34) treated with YTT for 24 weeks. The changes of Alzheimer’s disease assessment scale (ADAS-COG),Clinician Interview based Im-pression of Severity (CIBIC-PLUS) and Mini-mental State Examination (MMSE) were evaluated before and after treatment.The lev-els of interleukin-6 (IL-6),interleukin-8 (IL-8) and tumor necrosis factor-α(TNF-α) were observed. Results After 24 weeks of treatment,the scores of ADAS-COG,CIBIC-PLUS and MMSE were better in treatment group than that in control group ( P＜0.05). There were significant differences in the scores of ADAS-COG,CIBIC-PLUS and MMSE before and after treatment ( P＜0.05). After treatment,the levels of IL-6,IL-8,TNF-αwere decreased in treatment group,which were lower than that in control group (P＜0.05). Conclusion YTT can delay the development of cognitive impairment in patients with VCIND to a certain extent,and may delay the progression by modulating the associated inflammatory factors.
Keywords：vascular cognitive impairment with non-dementiaYinxin Tongzhi tabletinterleukin-6interleukin-8tumor necrosis factor-α
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1439-1442 )