The Effect of Sevoflurane Anesthesia Induction in Congenital Heart Disease and Its Protection on Brain and Myocardium
Du Shoufeng
Shi Wenhua
Sun Junjun
Abstract：Objective To investigate the effect of sevoflurane anesthesia induction in congenital heart disease and its protection on brain and myocardium. Methods Ninety-eight children with congenital heart disease from November 2013 to November 2016 were randomly divided into two groups:control group ( n=49) induced with ketamine,and research group ( n=49) induced with sevoflu-rane. The anesthesia effect,radial artery blood oxygen content (CjvO2) and radial artery blood oxygen saturation (SjvO2),creatine ki-nase isoenzyme (CK-MB),creatine phosphokinase (CK),cardiac troponin I (cTnI),and complications were compared. Results The wake up time,extubation time in research group were less than that in control group ( P＜0.05). There was no difference in preopera-tive CjvO2,SjvO2,CK-MB,CK,cTnI between two group(P＞0.05). The postoperative CjvO2,SjvO2 were reduced in two groups,which were higher in research group than that in control group ( P＜0.05). The postoperative CK-MB,CK,cTnI were rised,which were lower in research group than that in control group ( P＜0.05). There was no difference in the complications between two group ( P＞0.05). Conclusion Sevoflurane anesthesia induction can protect the brain and myocardium in congenital heart disease.
Keywords：congenital heart diseasesevofluranebrain protectionmyocardial enzymescardiac troponin Iblood oxygen contentblood oxygen saturation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1397-1400 )