Study on the Mechanism of Salvia Miltiorrhiza in the Treatment of Heart Failure Predicted by Network Pharmacology
Zeng Zifan
Ren Yinglu
Wang Yong
Li Chun
Wang Wei
Abstract：Objective To study the main active ingredients and potential targets of Danshen (Salvia miltiorrhiza),and to investigate the mechanisms of diseases-targets-compounds intervention of Danshen on heart failure (HF) and congestive heart failure (CHF). Methods The main targets of the active ingredients of Danshen were predicted and screened according to the bioinformatics analy-sis tool (BATMAN-TCM). Targets-compounds network of Danshen treating HF was constructed by Cytoscape software. The simi-larities and differences of Danshen treating HF and CHF were analyzed by Venn diagram. Results Twelve active ingredients and 13 targets which involving angiotensin-converting enzyme (ACE),ADRA2A and ADRA2B,etc. of Danshen on HF was selected.There was an effective interaction between ingredients and predicted targets. Conclusion Danshen can improve heart function and treat heart failure probably through its bioactive ingredients such as Miltirone,Tanshiquinone,and Neotanshinone,etc.,and related targets such us angiotensin-converting enzyme,adrenoceptorα2 andβ2,etc.
Keywords：heart failurecongestive heart failurenetwork pharmacologyDanshen (Salvia miltiorrhiza)targetingredientmechanism
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1353-1358 )