Correlation between Executive Dysfunction and Serum Endothelin-1 in Elderly Patients with Obstructive Sleep Apnea Hypopnea Syndrome Complicated with Acute Intracerebral Hemorrhage
Sun Jianying
Guo Xia
Wang Hongyang
Abstract：Objective To investigate the correlation between executive dysfunction and serum endothelin-1 (ET-1) in elderly patients with obstructive sleep apnea hypopnea syndrome ( OSAHS) complicated with acute intracerebral hemorrhage. Methods Two hundreds and sixty-four elderly patients of OSAHS complicated with acute intracerebral hemorrhage were chosen as observed ob-jects,and they were divided into non-executive function impairment group and executive function impairment group according to the assess of behavioral assessment of dysexecutive syndrome (BADS).Univariate and multiple analysis were conducted in the potential impacting factors of executive function impairment including age,gender,the level of education,Body Mass Index (BMI),bleeding site,a-mount of bleeding,OSAHS degree,combined other chronic diseases and serum ET-1 between two groups.Pearson analysis was con-ducted to analyze the correlation between executive dysfunction with serum ET-1.Results Serum ET-1 was independent impac-ting factors of executive dysfunction after acute intracerebral hemorrhage in elderly patients with OSAHS.The risk of executive dys-function was significantly increased in patients with high level of serum ET-1 than that in patients with normal level[χ2=13.33, P=0.000,RR=1.913,95% CI (1.592,6.096)].Pearson correlation analysis showed that serum ET-1 levels were negatively correlated with BADS scores ( P＜0.01).Conclusion Elevated blood ET-1 level is an independent risk factor for executive dysfunction after acute intracerebral hemorrhage in elderly patients with OSAHS.The level of serum ET-1 is related to the degree of executive dysfunction.
Keywords：obstructive sleep apnea hypopnea syndromeintracerebral hemorrhageexecutive dysfunctionendothelin-1correlation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1346-1349 )