Effects of Levamlodipine and Tianma Gouteng Granules on the NT-ProBNP and Carotid Vascular Intima Thickness in Patients with Hypertension
Hang Liang
Zhang Yonggang
Tian Huijuan
Abstract：Objective To study the effects of levamlodipine and Tianma Gouteng granules (TGG) on the N-terminal type B natriuretic peptide (NT-ProBNP) and carotid vascular intima thickness in patients with hypertension. Methods Ninety-four patients with hy-pertension from February 2015 to February 2017 in our hospital were selected and randomly divided into two groups:control group (n=47) treated with levamlodipine besylate tablets,and observation group ( n=47) treated with levamlodipine and TGG in the basis of routine treatment for 8 weeks. The changes of blood pressure,plasma NT-ProBNP,carotid intima-media thickness (IMT) and endothelium dependent vasodilatation (FMD) were observed before and after treatment,and the clinical efficacy was compared. Results After treatment,the systolic blood pressure (SBP) and diastolic blood pressure (DBP) in two groups were significantly lower than that before treatment ( P＜0.05),which were significantly lower in observation group than that in control group( P＜0.05). The plasma NT-ProB-NP levels in two groups were significantly lower than that before treatment(P＜0.05),which was significantly lower in observation group than that in control group ( P＜0.05). The IMT in two groups were significantly lower than that before treatment,and FMD signif-icantly increased ( P＜0.05). The total effective rate in observation group was significantly higher than that in control group (93.62% vs 70.21% , P＜0.05). Conclusion The levamlodipine and TGG has a significant antihypertensive effect in patients with hypertension, and it’s helpful to decrease the expression of plasma NT-ProBNP and IMT.
Keywords：hypertensionlevamlodipineTianma Gouteng granulesN-terminal type B natriuretic peptidecarotid intima-media thick-nessendothelium-dependent vasodilatation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1327-1330 )