Correlation between Blood Stasis Syndrome and Anti Platelet Drug Resistance in Patients with Ischemic Stroke
Zhang Cuiyi
Huang Yan
Ma Jian
Ni Haobin
Cai Hanchao
Abstract：Objective To investigate the relationship between blood stasis syndrome and anti platelet drug resistance in patients with ischemic stroke.Methods One hundred and twenty-six patients with ischemic stroke were divided into non blood stasis syndrome group(n=39)and blood stasis syndrome group(n=87)according to the diagnostic criteria of blood stasis.All patients who were treated with dual antiplatelet therapy for more than one week were performed with the detection of thromboelastogram and the rate of platelet inhibition induced by arachidonic acid(AA)pathway and adenosine diphosphate (ADP)pathway was detected.The platelet inhibition rate and inhibitory effect were observed and compared between the two groups.Results The platelet inhibition rate of ADP receptor pathway in patients with blood stasis syndrome after ischemic stroke was lower than that of non blood stasis syndrome,the incidence of clopidogrel resistance was higher than that of non blood stasis syndrome(P<0.05).Conclusion For patients with is-chemic stroke,especially for patients with blood stasis syndrome,platelet inhibitory rate should be tested after oral anti platelet drug therapy in order to discover the phenomenon of anti platelet drug resistance timely.Chinese medicine for promoting blood circulation to remove blood stasis should be used according to syndrome differentiation when necessary.
Keywords：ischemic strokeblood stasis syndromeantiplatelet drug resistancearachidonic acidadenosine diphosphate
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 472-474 )