Mechanism of Signal Transduction and Traditional Chinese Medicine Treatment of Myocardial Fibrosis
Wang Yong
Zhou Yaozhong
Hang Yu
Qu Yang
Qu Huiyan
Zhou Hua
Abstract：Studies have confirmed that myocardial fibrosis is an important mechanism in the development of heart failure,it has impor-tant influence on the prognosis of heart failure.A variety of signal transduction mechanism was involved in the formation process of myocardial fibrosis.It can be divided into two kinds:the signal transduction mechanism promoting myocardial fibrosis formation(renin-angio-tensin-aldosterone system,transforming growth factor(TGF)-β1/Smads signaling pathway,inflammatory response,oxidative stress response)and the signal transduction mechanism inhibiting myocardial fibrosis formation(gp130-JAKs-STAT3 signaling pathway). Further research on the signal transduction mechanism of myocardial fibrosis can provide new targets for the clinical treatment of my-ocardial fibrosis.Traditional Chinese medicine can simultaneous treat the manifestation and root cause of myocardial fibrosis and has been proved an immense advantage.A variety of traditional Chinese medicine compound and single herbs has been proved to have inhibitory effects of myocardial fibrosis,but the signal transduction mechanism remains unclear.It is worth further discussing.
Keywords：heart failuremyocardial fibrosissignal transduction mechanismtraditional chinese medicine
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 421-424 )