Effects of Xinmailong Injection and Bisoprolol on the Hemodynamics and Serum hs-CRP,BNP,VEGF Levels in Patients with Heart Failure Caused by Coronary Heart Disease
Li Zhiguang
Ma Gaofeng
Yang Jun
Zhang Qianqian
Geng Shuxiang
Abstract：Objective To investigate the clinical efficacy of Xinmailong injection(XMLI)and bisoprolol on the hemodynamic and serum high-sensitivity C-reactive protein(hs-CRP),B-type natrigtetic peptide(BNP),vascular endothelial growth factor(VEGF)levels in patients with heart failure (HF)caused by coronary heart disease (CHD).Methods Two hundreds patients with HF caused by CHD from January 2014 to October 2016 were randomly divided into two groups:control group(n=100)treated with routine treat-ment plus bisoprolol,and treatment group(n=100)treated with routine treatment plus bisoprolol and XMLI.The clinical efficacy,hemo-dynamic changes,and changes of serum hs-CRP,BNP,VEGF levels were recorded and compared between the two groups.Results The total clinical effective rate was significantly higher in treatment group than that in control group after 5 days of treatment(94.0% vs 81.0%,P<0.01).Compared with those before treatment,the values of whole high viscosity,whole low viscosity,hematokrit (HCT) and plasma viscosity (PV)decreased remarkably in two groups after 5 days of treatment(P<0.01),which were lower in treatment group than that in control group after 5 days of treatment(P<0.01).After treatment,the serum hs-CRP and BNP levels decreased while VEGF level increase(P<0.01).The levels of serum hs-CRP and BNP were lower in treatment group than that in control group(P<0.01).The serum VEGF level was higher in treatment group than that in control group(P<0.01).Conclusion XMLI and bisoprolol can eliminate the clinical symptoms and improve hemodynamic indexes,which may be related to the improvement of serum hs-CRP,BNP and VEGF levels.
Keywords：coronary heart diseaseheart failureXinmailong injectionbisoprololhemodynamicsinflammatory factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 393-397 )