Effects of Wenxin Granule and Western Medicine on Cardiac Function,Serum hs-CRP and BNP Levels in Elderly Patients with Paroxysmal Atrial Fibrillation
Wang Jun
Guo Xiangdong
Zhao Yujie
Song Qiang
Zhang Songlin
Abstract：Objective To investigate the clinical efficacy of Wenxin granules(WXG)and western medicine on cardiac function,serum high sensitive C-reaction protein(hs-CRP)and B-type natriuretic peptide(BNP)levels in elderly patients with paroxysmal atrial fibrillation(PAF).Methods One hundred and sixty-two elderly patients with PAF from January 2016 to January 2017 were randomly divided into two groups:control group(n=81)treated with routine treatment,and observation group(n=81)treated with WXG and western medicine routine treatment for 6 months.The clinical efficacy,frequency and duration of AF outbreak before and after treat-ment,changes of heart function and serum hs-CRP,BNP levels,and the occurrence of adverse reactions were observed and com-pared between two groups.Results The frequency and duration of AF outbreak after 6 months of treatment significantly decreased compared with those before treatment(P<0.01),and the improvement in observation group was more significant than that in the control group(P<0.01).The total clinical effective rate was significantly higher in observation group than that in control group(95.1% vs 80.2%,P<0.05).Compared with those before treatment,the values of left ventricular ejection fraction (LVEF),left ventricular end diastolic/sys-tolic diameter (LVEDD/LVESD)and P wave dispersion(Pd)in two groups after treatment were improved remarkably (P<0.01), and the improvement in the observation group was more significant (P<0.01).The serum hs-CRP and BNP levels in two groups after treatment were obviously lower than those before treatment (P<0.01),and the improvement in the observation group was more significant (P<0.01).There was no difference in the of incidence adverse reaction between two groups(6.17% vs 3.70%,P>0.05).Conclusion WXG and western medicine routine treatment can greatly improve the cardiac function and lower serum hs-CRP and BNP levels in elderly patients with PAF.
Keywords：paroxysmal atrial fibrillationWenxin granulescardiac functionhigh sensitive C-reaction proteinB-type natriuretic pep-tide
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 389-393 )