Effects of Levocamitine and Atorvastatin Calcium on Cardiac Function,Serum CRP,IL-6 and TNF-α Levels in Patients with Chronic Heart Failure
Li Zhiguang
Ma Gaofeng
Wang Xue
Shan Weijie
Geng Shuxiang
Abstract：Objective To explore the effects of levocarnitine (LC) and atorvastatin calcium (AC) on cardiac function,serum C-reactionprotein (CRP),interieukin (IL)-6,and tumor necrosis factor (TNF)-α in patients with chronic heart failure (CHF).Methods One hundreds and forty-four patients with CHF in our hospital from June 2015 to June 2017 were randomly divided into two groups:control group (n =72) treated with AC,and treatment group (n =72) treated with AC and LC for 4 weeks.The clinical effect,the changes of cardiac function and serum CRP,IL-6,TNF-α levels were observed before and after treatment,as well as adverse reaction were observed.Results After 4 weeks of treatment,the total clinical effective rate was significantly higher in treatment group than that in control group (91.7％ vs 69.0％,P ＜0.01).Left vertricular end diastolic diameter(LVEDD)/left vertricular end systolic diameter (LVESD),and serum CRP,IL-6,TNF-α levels decreased while left ventricular ejection fraction (LVEF) increased in two groups after treatment (P ＜0.01).The cardiac function was better in treatment group than that in control group (P ＜ 0.01).There was no difference in the adverse reaction rate between treatment group and control group (4.2％ vs 5.6％,P ＞0.05).Conclusion LC and AC can relieve the symptoms and signs and improve the cardiac function effectively in patients with CHF.It may be related to the improvement of serum CRP,IL-6 and TNF-α levels in patients.
Keywords：chronic heart failurelevocarnitineatorvastatin calciumcardiac functioninflammatory factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 323-326 )