The Influence of HDL-C on Endothelial Function in Patients with Acute Myocardial Infarction and Stable Angina Pectoris
Li Yun
Cao Deyong
Abstract：Objective To study the effect of high density lipoprotein (HDL-C) on endothelial function in patients with acute myocardial infarction (AMI) or stable angina (SA).Methods Gradient centrifugation was used to centrifuge HDL from normal volunteers (control group,n =28),AMI patients (AMI group,n =25) and SA patients (SA group,n =25).The effects of HDL on endothelial nitric oxide synthase (eNOS) and its phosphorylation sites at S1177 expression,levels of nitric oxide (NO) and oxygen free radical (O2 ·-) in human umbilical vein endothelial cells (HUVEC) were detected.Results There was no significant difference in eNOS expression,NO and O2 ·-levels in HUVES between SA group and control group (P ＞0.05).Compared with SA group,the expression of eNOS and its phosphorylation sites at S117 were inhibited,NO level decreased,and the O2 ·-content increased in AMI group (P ＜0.05).Conclusion HDL-C damage endothelial function by inhibiting eNOS/NO/O2 ·-pathway in AMI patients.
Keywords：acute myocardial infarctionstable anginahigh density lipoproteinendothelial cellnitric oxide synthase
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 315-319 )