Effects of Bushen Yixin Tablets on the Erectile Function and Penis Cavemosum In Spontaneously Hypertensive Rats
Wang Shichao
Liu Fang
Liu Yude
Chu Qingmin
Wu Wei
Wu Hui
Li Rong
Sun Ce
Wang Song
Qing Lijin
Gong Zhaohui
Abstract：Objective To observe the effects of Bushen Yixin tablets (BYT) on blood pressure,erectile function,the levels of nitric oxide synthase (NOS),nitric oxide (NO) and angiotensin (Ang) (1-7) in spontaneously hypertensive rats (SHR).Methods SHR were divided randomly into 3 groups:BYT group (n =5),valsartan group (n =5),and model group (n =6).SHR were given BYT,valsartan and saline by gavages,respectively.After 4 weeks,the concentration of NOS,NO,Ang (1-7) in corps caverneux of NOS,NO in aorta were observed.The penile erection erectile function was detected by subcutaneous injection of apomorphine (APO).Results The concentration of NO in corps caverneux was significantly lower in BYT group than that in model group.The concentration of NO and Ang (1-7) in corps caverneux was significantly higher in BYT group than that in model group.The concentration of NO in corps caverneux was significantly higher in BYT group than that in valsartan group.The blood pressure decreased obviously in BYT group and valsartan group after treatment,there was significant difference compared with those before treatment.After treatment,erectile number increased obviously in BYT group and valsartan group,there was significant difference.Conclusion BYT can improve the erectile function,and increase plasma NO level in aorta and Ang (1-7) level in in SHR.
Keywords：spontaneously hypertensive ratsBushen Yixin tableterectiledysfunctionACE2-Ang (1-7)-MAS axis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 295-298 )