The Role of Adventitial Fibroblast in Atherosclerosis and Restenosis Post-PCI
Li Tong
Zhao Mingjing
Han Xiaowan
Zhao Yizhou
Yang Tao
Wang Lei
Wang Baofu
Zhang Jing
Jing Ji
Abstract：The vascular adventitia is an active participant of vascular remodeling diseases like atherosclerosis (AS) and restenosis post-PCI.More and more researches indicated that adventitia not only plays a supporting and nutritional role to blood vessels,but also participates in the process of AS and restenosis post-PCI.As the most important component of adventitia,the adventitial fibroblast results in thickening of adventitia and intima,and luminal stenosis by activating,proliferating,migrating,secreting cytokines and extracellular matrix.In addition,activated fibroblast also promotes the formation of AS and restenosis post-PCI by taking part in the regulation of nitric oxide,oxidative stress and inflammatory response.This review presents the new research trends and development on the role of adventitial fibroblast in atherosclerosis and restenosis post-PCI.
Keywords：atherosclerosisadventitial fibroblastpercutaneous coronary interventionrestenosispathogenesis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 49-53 )