Therapeutic Effect of Lateral Ventricle Transplantation of NSCs in Rats with Cerebral Palsy
Wei Yan
Tao Jing
Xie Rong
Abstract：Objective To investigate the therapeutic effect of lateral ventricle transplantation of neural stem cells (NSCs) in rats with cerebral palsy.Methods Sixty 7-day-old,SPF grade wistar rats were selected.Twelve rats were selected randomly as the normal group (saline treatment),the other 48 rats were established as cerebral palsy rat model.Twenty-four successful modeling rats were randomly divided into model group (saline treated) and NSCs group (NSCs transplantation therapy).The neurobehavioral school test results and periventricular white matter glial fibrillary acidic protein (GFAP) content of rats after 42 days were compared.Results At 42 days of age,Morris water maze escape latency and periventricular white matter in GFAP positive cells of model group was significantly higher than that of NSCs group and the normal group (P ＜0.05).Morris water maze escape latency and periventricular white matter in GFAP positive cells of NSCs group was significantly higher than that of normal rats (P ＜0.05).At 42 days of age,the slope experiment time of model group was significantly longer than that of NSCs group and normal group,while hanging test and open-field test scores were significantly lower than the NSCs group and the normal group (P ＜0.05).The slopeexperiment time of NSCs group was significantly longer than that of normal group,while hanging test and open-field test scores were significantly lower than that of normal group (P ＜0.05).Conclusion The lateral cerebral ventricle transplantation of NSCs can significantly improve neurobehavioral and learning ability in rats with cerebral palsy.
Keywords：cerebral palsylateral ventricleneural stem cellstransplantationrat
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3121-3124 )