Effects of Trimetazidine on the Cardiac Function and Ultrastructure in Rats with Heart Failure after Myocardial Infarction
Shi Jie
Abudujilili
Shang Xiuyang
Hu Yuanhui
Abstract：Objective To study the effect of trimetazidine on cardiac function and ultrastructure in heart failure rats after myocardial infarction.Methods Ligation of left anterior descending coronary artery was performed in myocardial infarction-induced heart failure models in rats.Rats were randomly divided into sham group,model group and trimetadizine group after the success of building.Echcardiography was used to observe cardiac function changes of rats.Hematoxylin-Eosin (HE) staining and Masson staining were used to observe histopathologic changes of myocardial tissue under light microscope.Results Compared with the rats in model group,left ventricular internal diameter at diastole (LVIDd) and systole (LVIDs) in trimetadizine group were significantly reduced after 8 weeks'drug therapy.The ejection fraction (LVEF),fractional shortening (FS) and cardiac output (CO) in trimetadizine group were increased obviously.Under light microscope,HE staining showed that there was wide range of myocardial infarction and disordered arrangement of myocardial fibers in model group cells.A lot of collagen fibre tissues were seen,while granulation tissue rared.In trimetadizine group,there was limited myocardial infarctions area.Myocardial fiber arrangement was irregular.Fibroblast and granylation tissue hyperplasia increased more than model group.Masson staining showed that myocardial cell were hypertrophied,arranged disorderly,and some were supplemented by collagen tissues in model group.The partial myocardial cells were replaced by collagen fibers and collagen fibers were mingled with myocardial cells in trimetadizine group.Conclusion Trimetazidine can effectively improve the contractile function of heart failure rats after myocardial infarction,and improve myocardial ultrastructure and inhibit the pro liferation of extracelluiar matrix collagen fibers.
Keywords：heart failure after myocardial infarctiontrimetazidineratscardiac functionultrastructure
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3114-3118 )