Study on the Early Evaluation and Screening Method of Heart Failure Model after Myocardial Infarction from the Correlation Analysis of Electrocardiogram and Ultrasonic Cardiogram
Wang Lei
Zhao Mingjing
Yang Tao
Zhao Yizhou
Chen Huiyang
Cheng Wenkun
Lu Ziwen
Han Xiaowan
Li Tong
Wang Baofu
Abstract：Objective To establish a new method for early evaluation and screening of heart failure (HF) model after myocardial infarction (MI) and provide basis for early random grouping on drug intervention study.Methods Sprague-Dawley (SD) rats were randomly divided into model and sham group.The rats in MI models were established by ligating left anterior descending coronary artery,while sham rats underwent thoracotomy without ligation.The 12-lead electrocardiogram (ECG) were detected for the two groups on 2nd,10th and 60th day after operation.On the 10th and 60th post-operative day,the ultrasonic cardiogram were detected.Then the correlation between the different time point's pathological Q wave and ejection fraction (EF) and fractional shortening (FS) was analyzed.Results There was a significant negative correlation between the number of different time point's pathological Q wave and EF and FS index.Pathological Q waves were distributed in V3～V6,Ⅰ and aVL leads,with both V1 and/or V2 leads if the EF＜ 50％.When the EF＜30％,besides the above leads,it also extended to the single or multiple inferior wall leads of Ⅱ,Ⅲ,aVF due to the mirror effect.The specificity,sensitivity and accuracy of early screening of animal models with 2nd day pathological Q wave were 100.0％,95.0％ and 96.7％.Conclusion Different time point's pathological Q wave had significant negative correlation with EF and FS,which could be used for early screening of HF after myocardial infarction models.The study provides reliable experimental evidence for early evaluation and randomization of pharmacological experiments.
Keywords：myocardial infarctionheart failureelectrocardiogramultrasonic cardiogrammodel evaluation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 2816-2820 )