Comparative Study on the Determination of Small Dense Low Density Lipoprotein by Direct and Formula Methods
Wu Xusheng
Li Hongfan
Song Xiangjing
Yang Haisong
Cao Runhong
Song Zexing
Duan Linlin
Wang Zhangsheng
Abstract：Objective To study the difference between direct and formula method for the determination of small dense low density lipoprotein (sdLDL).Methods Three thousands,three hundreds and forty-six blood samples were collected from July to November in our hospital,and tested for serum lipids,including total cholesterol (TC),low density lipoprotein (HDL) and triglyceride (TG).And then according to the type of hyperlipidemia,the sdLDL results were determined by direct and formula methods.Results There was a correlation between the content of sdLDL measured by direct method and formula method in all types of hyperlipidemia and normal control group.The correlation between the normal control group and the low HDL-C group was the best (correlation coefficient was 0.830 and 0.831,reppectively).There was no significant difference between the direct method and the formula method in the mixed hyperlipidemia group and the low HDL-C group.Conclu0sion The sdLDL can be applied to screening healthy population,but it is necessary for patients with hyperlipidemia to determine the content of sdLDL by direct method to provide reliable test data for clinical diagnosis and treatment.
Keywords：direct methodformula methodsmall dense low density lipoproteinserum lipids
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2418-2420 )