Effects of Danhong Injection and Fasudil Hydrochloride Injection on Hemorheology and Neurological Function in Patients with Ischemic Cerebral Infarction
Du Yingchun
Xue Wenjun
Qin Deying
Li Weidong
Li Weigang
Abstract：Objective To study the effects of Danhong injection and fasudil hydrochloride injection on hemorheology and neurological function in patients with ischemic cerebral infarction.Methods Seventy-six patients with ischemic cerebral infarction in our hospital were selected from January 2015 to February 2016.According to the order of admission into groups,they were divided into two groups:control group (n=38) treated with fasudil hydrochloride injection,and study group (n=38) treated with fasudil hydrochloride injection and Danhong injection for 14 days.The indexes of daily living and neurological deficits,hemorheological indexes (fibrinogen,hematocrit,plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity),triglyceride(TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were compared between the two groups before and after treatment.And the incidence of adverse reactions were statistically analyzed.Results There was no significant difference in BI and NIHSS scores between two groups before treatment (P>0.05).After treatment,the difference between the study group and the control group was statistically significant (P<0.05).There was no significant difference between the two groups before treatment (P>0.05).After treatment,the levels of fibrinogen,hematocrit,plasma viscosity,whole blood high shear viscosity,whole blood low (10.52%) and the control group (13.15%) were significantly higher than those in the control group (P<0.05),and the difference was statistically significant (P<0.05) No statistical significance (P>0.05).Conclusion The combination of Danhong injection and fasudil hydrochloride injection can significantly improve the level of blood lipid and hemorheology,and improve the neurological function and daily living ability.and the incidence of adverse reactions was lower.And the safety is more reliable,with the promotion of value.
Keywords：ischemic cerebral infarctionDanhong injectionfasudil hydrochloride injectionhemorheologyneurological functionstroke
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1647-1650 )