Effect of the Delay of Thrombolytic Therapy and the Incidence of MACE in Inpatients with ST-segment Elevation Acute Myocardial Infarction
Hao Cuiping
Abstract：Objective To investigate the effect of the delay of thrombolytic therapy and the incidence of major adverse cardiac events (MACE) in inpatients with ST-elevation acute myocardial infarction (STEMI).Methods A total of 240 patients underwent thrombolytic therapy with STEMI from April 2013 to May 2016 were categorized into recanalization group (n=168) and non-recanalization group (n=72),were employed.The patients were stratified in 0 h to 5.9 h,6 h to 11.9 h and ≥12 h respectively in each group according to the time receiving thrombolysis therapy.The Multifactor Logistic regression model was performed to investigate the relationship between the delay of thrombolytic therapy and the incidence of MACE in patients with STEMI.Results In recanalization group,the risks of MACE adjusted confounding factors in patients receiving thrombolytic therapy in 6 h to 11.9 h and more than 12 h were increase which compared with 0 h to 5.9 h group.The same effect was presented in non-recanalization group.Conclusion Thrombolytic therapy should be carried out within 6 hours in patients with STEMI,MACE rates were significantly increased in patients with more than 12 hours' treatment delay.
Keywords：ST-elevation acute myocardial infarctionthrombolysismajor adverse cardiac events
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1592-1595 )