The Influence of Guantong Decoction on Pathologic Morphology and Myocardial-Cell Apoptotic Index in Rabbits with Myocardial Ischemia Reperfusion Injury
Wei Bin
Wang Qiang
Jiang Hao
Zhu Zhihua
Chen Guangqin
Yin Wei
Luo Hong
Abstract：Objective To observe the effect of Guantong decoction(GTD) on pathologic morpho logy in rabbits with myocardial ischemia reperfusion injury.Methods Forty-eight New Zealand white rabbits were randomly divided into 6 groups,namely sham group,normal control group,GTD high dose group,GTD moderate dose group,GTD low dose group and drug control group.The rabbits were taken medicine for 14 days with designated drugs.GTG groups were taken different dose medicine of GTD,and sham operation group and normal control group were pretreated by distilled water.The model of myocardial ischemia-reperfusion injury were established by ligating the left anterior descending artery of New Zealand rabbits for forty minutes after taken medicine for one hour and no coronary artery injury were in sham group.The heart were made into pathological sections and stained with HE and TUNEL.Apoptotic index was detected with electron microscope in times of four hundreds.Results Myocardial injury cells and apoptotic index of GTD high dose group and moderate dose group were less than normal control group and GTD small dose group (P<0.05).Conclusion GTD can effectively protect myocardial cell in rabbits with myocardial ischemia reperfusion injury.
Keywords：myocardial ischemia reperfusion injuryGuantong decoctionmechanism research
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1569-1572 )