Effects of Xingnaojing Injection and Ginkgo Biloba Extract Injection on the Levels of MMP-9,BNP and Serum Cystatin C in Elderly Patients with Acute Cerebral Infarction
Li Chunlei
Zhang Feng
Abstract：Objective To investigate the effects of Xingnaojing injection (XNJI) and Ginkgo biloba extract injection (GBEI) on the levels of matrix metalloproteinase-9 (MMP-9), brain natriuretic peptide (BNP) and serum cystatin C (Cys-c) in elderly patients with acute cerebral infarction (ACI).Methods One hundred and twenty-six elderly patients with ACI were randomly divided into two groups:control group (n=63) treated with routine treatment,and treatment group (n=63) treated with routine treatment plus XNJI and GBEI.The clinical curative effect, National Institutes of Health Stroke Scale (NIHSS) scores,cerebral hemodynamics, MMP-9, BNP and Cys-c levels were observed.Results The cure rate and total clinical effective rate were 36.5% and 92.1% in treatment group,which was significantly higher than that in control group (19.0%, 77.8%,P<0.05).After treatment of 1 weeks and 2 weeks, NIHSS scores and MMP-9, BNP levels decreased,which was lower than that in control group (P<0.05) , and gradually decreased.The levels of DVp increased, which was higher than that in control group (P<0.05) , and gradually increased.Conclusion XNJI and GBEI can decrease the level of inflammatory cytokines, improve cerebral hemodynamics in patients with ACI.
Keywords：acute cerebral infarctionXingnaojing injectionGinkgo biloba extract injectioncerebral hemodynamicsmatrix metalloproteinase-9brain natriuretic peptideserum cystatin C
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1435-1438 )