Effects of Songling Xuemaikang Capsule on Different Blood Pressure Grades for Essential Hypertension Evaluated by Generalized Estimation Equation
Dong Zhenyu
Wu Shengxian
Gao Ying
Yang Wei
Guo Shengnan
Xu Lei
Abstract：Objective To evaluate the effect of Songling Xuemaikang capsule (SXC) on different blood pressure grades of essential hypertension (EH) by generalized estimation equation (GEE).Methods Real-world study method was used,and 2 974 patients with EH taking SXC were included.According to the use of western medicine (WM) antihypertensive drugs or not, patients were divided into SXC group (n=1 544), combined group (n=1 430, SXC plus WM antihypertensive drugs) for the treatment of 8 weeks and followed up every 2 weeks.Bsaed on correlation among repeated measures and to establish GEE in consideration the confounder to compare the efficacy of systolic blood pressure (SBP) and diastolic blood pressure (DBP) between different time points, groups and blood pressure grades.Results The efficacy in patients with grade 1 of SBP in SXC group was similar to combined group (P>0.05).The efficacy in patients with grade 1 of DBP in SXC group was similar to combined group after 2, 4 and 6 weeks of treatment (P>0.05).The efficacy in combined group was better than that in SXC group after 8 weeks (P<0.001).The efficacy in patients with grade 2 of SBP in combined group was better than that in SXC group at different time points (P<0.001).The efficacy in patients with grade 2 of DBP in SXC group was similar to combined group at different time points (P>0.05).The efficacy in patients with grade 3 of SBP and DBP in combined group was better than that in SXC group at different time points (P<0.001).Conclusion SXC has the advantage on lowering DBP with grade 2 and 3 in patients with EH.
Keywords：essential hypertensiongeneralized estimating equationSongling Xuemaikang capsulereal-world study
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1428-1432 )