The Effectiveness and Safety of Promoting Circulation to Remove Stasis in the Treatment for Essential Hypertension: System Review and Meta Analysis
Zhao Yajun
Su Xiaohong
Guo Yuanyuan
Abstract：Objective To evaluate the effectiveness and safety of the method of promoting blood circulation to remove blood stasis in the treatment for essential hypertension (EH).Methods PubMed, Cochrane Library, EMBASE, Wiley, Ovid, Clinical Trials.gov, Cochrane Central Register of Controlled Trials, VIP, ChiCTR, CBM, CNKI, and Wanfang were searched to identify relevant studies.Studies were identified and selected, and data were extracted by two independent reviewers.The Cochrane Risk of Bias tool was used to assess the quality of studies.Revman 5.3 software was used for date synthesis and analysis.Results In this review,twenty-six studies,3 288 patients of EH were included based on the selection criteria.In the overall analysis, promoting blood circulation to remove blood stasis resulted in significantly higher antihypertensive effective rate [OR=2.73,95% CI(1.94,3.85)]and symptom effective rate[OR=4.97,95% CI(3.04,8.13)] lower levels of systolic blood pressure [SMD=-0.40,95% CI(-0.61-0.91)]and diastolic blood pressure[SMD=-0.54,95% CI(-0.76,-0.33)],syndrome integral [MD=-4.71,95% CI(-6.17,-3.25)],improve ment of the quality of life improve the quality of life and the security as compared to that of western medicine treated to Primary Hypertension.Sensitivity analysis indicated that findings of the meta-analysis were robust to study quality and funnel plot showed no publication bias.Conclusion Currently, the evidence supports the method of ''promoting blood circulation to remove blood stasis''could improve the antihypertensive effects of primary hypertension, the clinical symptoms and quality of life of patients.Besides, the security is betfer.
Keywords：essential hypertensionpromoting circulation and removing stasisrandomized controlled trialssystem reviewmeta analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 1417-1427 )