Correlations between NT-ProBNP,hsTropT,hs-CRP Levels and other Related Functional Lndicators with Prognosis in Patients with Acute Heart Failure
Wang YouHe
Abstract：Objective To investigate the correlation between N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitivity Troponin T (hsTropT), high sensitivity C-reactive protein (hsCRP),other related functional parameters and the prognosis in patients with acute heart failure (AHF).Methods Two hundreds and seventy-four patients with AHF were treated in our hospital from January 2011 to December 2014.The general clinical data and medical records were analyzed when they were admitted to hospital.The clinical data were analyzed including age,sex,height,weight, body mass index (BMI),smoking,drinking,ischemic heart failure,hemoglobin,hsCRP,alanine aminotransferase, aspartate aminotransferase,creatinine,albumin,total cholesterol,high density lipoprotein,low density lipoprotein,triglyceride,apolipoprotein A,apolipoprotein B,initial NT-proBNP,48 hours NT-proBNP,hsTropT,left ventricular diastolic diameter,left ventricular systolic diameter,left ventricular ejection fraction,American New York Heart Association (NYHA) information heart function classification,adverse events and death cases.Results There were 226 cases in HF-REF group and 48 cases in HF-PEF group.Comparison between the age,diabetes,hypertension,initial NT-proBNP,48 hours NT-proBNP,hsTropT,diastolic left ventricular diameter,left ventricular systolic diameter,left ventricular ejection fraction, NYHA heart function classification and death cases of two group,the differences was statistically significant (P<0.05).Patients with adverse events were 90 cases (32.8%),including 33 cases of death (the total mortality rate of 12%),18 cases of heart failure continue to deteriorate and 39 cases of developing refractory heart failure (NYHA grade Ⅲ or IV grade).There were 184 patients in the adverse event group and 90 in the non adverse event group.Comparison between the age,diabetes,hsCRP,initial NT-proBNP,48 hours NT-proBNP, NYHA heart function classification,follow-up time of two group,the difference was statistically significant (P<0.05).The results of multivariate logistic regression analysis showed that the initial NT-proBNP(OR=5.16,95% CI:1.67 to 44.46,P=0.004), 48 hours NT-proBNP (OR=4.27,95% CI:1.96 to 37.43,P=0.016) and NYHA (OR=3.22,95% CI:1.37 to 7.52,P=0.039 classification) were independent prognostic factors of patients with AHF.Conclusion The initial NT-proBNP and 48 h NT-proBNP showed an obvious correlation,which can be used as an important indicator for clinical diagnosis and prognosis evaluation.
Keywords：acute heart failureN-terminal pro-brain natriuretic peptidehigh sensitivity Troponin Thigh sensitivity C-reactive proteinprognosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1221-1225 )