Clinical Study of Interventional Stent Implantation for Carotid Artery Stenosis and Its Effects on Inflammatory Factors,Coagulation Function and Neurological Function
Tian Rong
Mao Gengsheng
Li Dongmei
Du Shiwei
Nie Qingbin
Sun Jian
Chen Lin
Zhang Yudan
Abstract：Objective To study the clinical effect of interventional stent implantation for carotid artery stenosis and its effects on inflammatory factors, coagulation function and neurological function.Methods Seventy-six patients with carotid stenosis were selected and divided into two groups:control group (n=38) treated with carotid angiography,and treatment group (n=38) treated with interventional stent implantation.The clinical treatment effect,the changes of inflammatory factors, coagulation factors, and neurological deficits, daily living ability and complications were observed.Results After treatment, the scores of National Institutes of Health Stroke Scale (NIHSS) and Rankin Scale in two groups were significantly improved,which was lower in treatment group than that in control group (P<0.05).The levels of inflammatory factors in treatment group were higher than that in control group,which lasted for one week, and the level of postoperative changes was significant compared with preoperative (P<0.05).The levels of fibrinogen (FIB),D-dimer (DD), fibrin degradation product (FDP) after operation and prothrombin time (PT) and activated partial thromboplastin time (APTT) in treatment group were significantly higher than those in control group at 1st day after operation (P<0.05).The scores of Barthel index and Scandinavian Stroke Scale (SSS) in treatment group were significantly improved and better than those in control group (P<0.05).The incidence of complications in treatment group was significantly higher than that in the control group (P<0.05).Conclusion The clinical effect of interventional stent implantation in the treatment of carotid artery stenosis is significant, although the levels of coagulation factors, inflammatory factors and neurological function have a certain impact in patients with carotid stenosis,which was significantly improved after 1 week of surgery.
Keywords：carotid stenosisinterventional stent implantationinflammatory factorcoagulation factorneurological function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1124-1128 )