Effects of Compound Gouteng Jiangya Tablets on Blood Pressure and Morphology of Myocardium and Renal Artery in Spontaneously Hypertensive Rats
Li Su
Tan Yuansheng
Abstract：Objective To observe the effects of compound Gouteng Jiangya tablets (CGJT) on blood pressure and morphology of target organ organization in spontaneously hypertensive rats (SHR).Methods Thirty-two 11-week-old SHR were randomly divided into 3 groups:model group(SHR-M group,n= 8),SHR-CGJT group (n= 16),and SHR-telmisartan group (n= 8).Eight 11-week-old wistar rats were selected as blank control group.After 8 weeks, blood pressure was measured for 5 times.The morphologic changes of myocardium and renal artery were observed by Hematoxylin-Eosin (HE) and Masson staining.Results Compared with SHR-M group, blood pressure reduced in SHR-CGJT group and SHR-telmisartan group (P<0.05).The morphologic changes of myocardium and renal artery were improved in SHR-CGJT group and SHR-telmisartan group.Conclusion CGJT has antihypertensive effect on SHR, can delays hypertensive left ventricular remodeling,slows down the process of myocardial fibrosis and renal artery vascular remodeling.
Keywords：spontaneously hypertensive ratscompound Gouteng Jiangya tabletsblood pressuremorphology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 931-934 )