Effect of Wenxiao Ⅱ Granule on the Expression of NF-κB P65 in Experimental Atherosclerosis Rabbits
Sheng Shumeng
Liang Rong
Huo Qingping
Abstract：Objective To observe the effect of different dose of Wenxiao Ⅱ granule (WXG) on the expression of nuclear factor-kappa B(NF-κB) P65 in experimental atherosclerosis rabbits,and explore its mechanism in treating atherosclerosis.Methods Thirty-eignt New Zealand rabbits were randomly divided into blank group (n= 9) and model group (n= 29).After 8 weeks,a rabbit was randomly killed in model group to confirm model established successfully.Then rabbits in model group were divided into 3 subgroups:WXG group,simvastatin group and model control group.The rabbits in three subgroups were treated with WXG,simvastatin,distilled water, respectively and fed with the standard food for another 8 weeks.At the end of experiment,all the rabbits were sacrificed.The expression of NF-κB P65 was determined by immunohistochemistry staining.Results Compared with the model group,the levels of NF-κB P65 decreased in WXG group and simvastatin group(P<0.05).There was significant difference in the level of NF-κB P65 between pre and post treatment in WXG group and simvastatin group (P<0.05).Conclusion WXG can inhibit the expression of NF-κB P65,which may stabilize plaque of atherosclerosis,reduce incidence of adverse events of cardiovascular and cerebrovascular disease.
Keywords：atherosclerosisWenxiao Ⅱ granulenuclear factor-kappa B P65rabbits
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 928-931 )