Effects of Shensong Yangxin Capsule and Wenxin Granule on Myocardial Fibrosis in Rats and Its Antiarrhythmic Mechanism
Wu Yanting
Chen Yun
Liu Haiting
Wu Yingying
Wu Wei
Liu Xincan
Abstract：Objective To study the effect of Shensong Yangxin capsule (SYC) and Wenxin granule (WXG) on myocardial fibrosis in rats and its antiarrhythmic mechanism.Methods Forty spontaneously hypertensive rats (SHR) were randomly divided into 4 groups: control group (n= 10) fed with normal feed, valsartan group (n= 10) fed with valsartan capsule content mixed feed, SYC group (n= 10) fed with SYC contents mixed feed, WXG group (n= 10) fed with WXG contents mixed feed for 2 months.After 2 months of feeding, rapid ventricular stimulation was performed, and the occurrence of arrhythmia was recorded.After the rats were killed, the left ventricular tissue sections were stained, the degree of fibrosis was observed.The expression of connexin 43 (Cx43), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix-metalloproteinase-2 (TIMP-2) in cardiac muscle cells was measured by immunohistochemistry.Results After feeding for 2 months, the occurrence of arrhythmia in valsartan group,SYC group,and WXG group were significantly less than that in control group (P<0.05).Quantitative image analysis showed that the expressions of Cx43 in valsartan group,SYC group,and WXG group were higher than that in control group (P<0.05) ,while the expressions of MMP-2 and TIMP-2 in valsartan group,SYC group,and WXG group were lower than that in control group (P<0.05).Conclusion SYC and WXG has the effects on myocardial remodeling, can delay the development of myocardial fibrosis, thereby reducing the incidence of fatal arrhythmia.The mechanism may be related to the increased expression of Cx43 and MMP-2.
Keywords：ventricular arrhythmiaShensong Yangxin capsuleWenxin granulemyocardial fibrosisconnexin 43matrix metalloproteinase-2tissue inhibitor of matrix-metalloproteinase-2
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 924-927 )