Clinical Observation of Midazolam with Quetiapine Fumarate in the Treatment of Alzheimer's Disease with Sleep Disturbance
Wang Jian
Abstract：Objective To study the effect of midazolam (midazolam maleate tablets) with quetiapine fumarate in the treatment of Alzheimer's disease (AD) with sleep disturbance.Methods One hundred and twenty-four patients with AD and sleep disturbance form Feb 2012 to Oct 2015 in our hospital were randomly divided into two groups:control group(n=62) treated with quetiapine fumarate,and treatment group(n=62) treated with quetiapine fumarate and midazolam.The scores of Pittsburgh Scale Sleep Quality Index (PSQI),Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD),Mini-mental Status Examination table (MMSE),and the ability of daily living (ADL) score using daily living scale were compared between two groups.Results After treatment,the PSQI score in treatment group was significantly lower than that in control group(P＜0.05).Compared with before treatment,the BEHAVE-AD scores were significantly decreased in two groups,while the scores of behavioral disorders,fear,rhythm disorder in treatment group was lower than that in control group (P＜0.05).Compared with before treatment,the MMSE scores in two groups were significantly increased,which was higher in treatment group than that in control group (P＜0.05).ADL scores in two groups were significantly increased,which was higher in treatment group than that in control group (P＜0.05).Conclusion Midazolam and quetiapine fumarate can improve the sleep quality,the mental,cognitive and life skills in patients with AD and sleep disturbance.
Keywords：Alzheimer's diseasesleep disturbancemidazolamquetiapine fumarateability of daily living
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 861-863 )