The Influence of Rosuvastatin on Cardiac Function and Endothelial Function in Patients with Acute Myocardial Infarction
Zhou Yu
Wang Mian
Abstract：Objective To observe the effects of rosuvastatin on cardiac function and endothelial function in patients with acute myocardial infarction (AMI).Methods Sixty patients with AMI were randomly divided into two groups:control group (n=30) treated with routine treatment plus atorvastatin,and treatment group (n=30) treated with routine treatment plus rosuvastatin for 28 days.The levels of brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO),endothelin (ET) were detected.The left ventricular end-diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),left ventricular ejection fraction (LVEF) were observed.The improvement of nitrog lycerinme-diated dilation (NMD) and the flow-mediated dilation (FMD) were compared.The infarct size,the electrocardiogram (ECG) QRS integral and complications were observed.Results After treatment,the levels of BNP,hs-CRP,LVEDD,LVESD,ET were decreased while the levels of FMD,NMD,LVEF were increased in two groups,the improvement was more significant in treatment group (P＜0.05).The scores of ECG QRS were lower in two groups,which was lower in treatment group than that in control group (P＜0.05).The infarct size and the incidence of reinfarction, severe arrhythmia, heart failure were lower in treatment group than that in control group (P＜0.05).Conclusion Rosuvastatin can improve cardiac function protection and endothelial function in patients with AMI.
Keywords：acute myocardial infarctionrosuvastatincardiac functionendothelial function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 826-830 )