The Influence of Ginkgobalide B on the Expression of C-fos,Caspase-3 and Caspase-8 in the Hippocampus of Alzheimer's Disease Rats
Hao Li
Xu Yuying
Tian Xinhong
You Yanwen
Xi Zhaoqing
Abstract：Objective To evaluate the efficiency of ginkgobalide B on the expression of c-fos,caspase-3 and caspase-8 in the hippocampus of Alzheimer's disease rats.Methods Rats were randomly divided into four groups:normal group,sham group,model group and Ginkgobalide B group.The Morris water maze (MWM) test was used to assess behaviors of the rats,Imunohistochemical staining was used to test c-fos in the hippocampal CA1.Real-time PCR and western blot were used to examine caspase-3 and caspase-8 mRNA and protein levels.Results MWM test result showed that escape latency was significantly shower and the times of crossing the platform increased.Imunohistochemical staining showed that c-fos increased in the hippocampal CA1 after ginkgobalide B (5 mg/kg) treatment.Real-time PCR and western blot manifested that compared with the model group,caspase-3 and caspase-8 decreased in the hippocampus after ginkgobalide B (5 mg/kg) treatment.Conclusion Ginkgobalide B can improve learning and memory in Alzheimer disease's rats,and its mechanism might be associated with neuronal apoptosis.
Keywords：Alzheimer's diseaseginkgobalide Blearning and memoryc-foscaspase-3caspase-8
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 798-801 )