Efficacy of Xinkeshu Tablet in the Treatment of Coronary Heart Disease with Anxiety Depression:A Meta-analysis
Yuan Liang
Dai Xiaohua
Abstract：Objective To systematically evaluate the efficacy of Xinkeshu tablet(XKST) in the treatment of coronary heart disease (CHD) with anxiety depression.Methods A computer search was performed using CNKI,CHKD,Wanfang,DuXiu and PubMed to identify the randomized controlled trials (RCTs) of XKST in the treatment of CHD with anxiety depression patients published up to November 2016,and relevant journals were manually searched.The identified studies were finally selected after full-text search and quality assessment and then subjected to meta-analysis using Review Manager 5.3.Results A total of 18 RCTs were included in the meta-analysis,one of them was carried from foreign literature and others were carried in China.Jadad score of 17 studies was 1,1 studies were 2.The meta-analysis showed that the XKST group had a significantly higher of efficacy than the control group in terms of the clinical efficacy,OR=4.69,95% CI[3.28,6.72],P＜0.000 01,improve electrocardiogram,OR=2.69,95% CI[2.02,3.57],P＜0.000 01,reduce the total cholesterol,WMD=-0.87,95% CI[-1.28,-0.47],P＜0.000 1,reduce low-density lipoprotein,WMD=-0.77,95% CI[-1.22,-0.32],P＜0.001,increase high-density lipoprotein,OR=0.11,95% CI[0.05,0.17],P＜0.001,improve the symptoms of anxiety,WMD=-12.53,95% CI[-13.68,-11.39],P＜0.000 01,improve the symptoms of depression,WMD=-12.25,95% CI[-16.27,-8.23],P＜0.01.Conclusion XKST can significantly improve the clinical efficacy,improve electrocardiogram,reduce the total cholesterol and low-density lipoprotein,increase high-density lipoprotein,improve the symptoms of anxiety and depression.
Keywords：coronary heart diseaseanxietydepressionXinkeshu tabletrandomized controlled trialmeta-analysischest Bi syndrome
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 772-776 )