Effects of Aspirin,Clopidogrel,and Ticagrelor on Platelet Function in Patients with Acute Coronary Syndrome before PCI Using Sono-clot Technique
Yang Wuxiao
Lai Chunlin
Chen Fuheng
Wang Jirong
Abstract：Objective To analyze the effect of aspirin plus clopidogrel and aspirin plus ticagrelor on platelet function in patients with acute coronary syndrome (ACS)before percutaneous coronary intervention (PCI)using Sonoclot technique. Methods Two hundreds and ten patients with cardiovascular disease from May 2013 to May 2015 in our hospital were diagnosed as ACS by coronary angiography. The patients were treated with PCI and randomly divided into two groups:group A (n=105)treated with 300 mg aspirin plus 600 mg clopidogrel,100 mg/d aspirin plus 75 mg/d clopidogrel next day,group B (n=105)treated with 300 mg aspirin plus 180 mg ti-cagrelor,100 mg/d aspirin plus 180 mg/d ticagrelor next day. The coagulation rate (CR),platelet function (PF)and the platelet inhibi-tion rate of two phosphate adenosine (ADP)pathway and the peanut four acid (AA)pathway were detected. The major adverse car-diovascular events (MACEs)and adverse drug reactions were observed. Ischemic events and bleeding events were followed up for 1 months,6 months,12 months. Results CR (18.35± 0.36),(18.01± 0.23),(17.88± 0.42)and PF (2.06± 0.14),(2.03± 0.12),(2.00 ± 0.08)in group B after 1 months,6 months,12 months were lower than those in group A [CR (20.51± 0.43),(20.34± 0.32),(20.16 ±0.25)and PF (2.06±0.14),(2.03±0.12),(2.00±0.08),P<0.05]. The platelet inhibition rates of ADP pathway were (65.08±16. 74)%,(65.36± 14.63)%,(65.83± 15.24)% in group A,(78.59± 21.25)%,(78.78± 21.36),(79.05± 20.24)% in group B,and there was significant difference between two groups (P<0.05). The platelet inhibition rates of AA pathway were (80.14± 18.25)%,(80.56 ± 20.13)%,(81.42± 21.02)% in group A,and (81.25± 20.31)%,(82.36± 20.27)%,(81.02± 20.14)% in group B,respectively,and there was no significantly difference between two groups (P>0.05). After 12 months follow up,there was no significant difference in MACEs between two groups (P>0.05). The incidence of dyspnea in group B was significantly higher than that in group A (P<0.05). Conclusion Aspirin plus grillo before PCI in patients with PCI after ACS is superior to aspirin plus clopidogrel in the inhibition of platelet.The events of ischemia or hemorrhage are similar in two groups.
Keywords：acute coronary syndromeaspirinclopidogrelticagrelorsonoclot techniqueplatelet function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 453-457 )