Effects of Jianxin Granules on the Expressions of Calcineurin mRNA and Urotensin Ⅱ RNA in Rats with Chronic Heart Failure
Wang Yong
Shi Dan
Cai Qixia
Li Zhipeng
Li E
Chen Meihua
Abstract：Objective To investigate the effects of Jianxin granules(JXG)on the expressions of calcineurin(CaN)mRNA and uroten-sin Ⅱ (UⅡ)RNA in rats with chronic heart failure (CHF). Methods Sixty-four 18-week-old spontaneously hypertensive rats (SHR)were randomly divided into 4 groups:perindopril group(n=16)intragastric administrated by perindopril 0.36 mg/(kg· d), JXG low dose group(n=16)intragastric administrated by 3.2 g/(kg·d),JXG high dose group(n=16)intragastric administrated by JXG 6.4 g/(kg·d),and negative control group(n=16)given saline solution. After administration of the 21st day,35th day,8 rats in each group were sacrificed. The expressions of CaN mRNA and UⅡ RNA were detected by fluorescence quantitative PCR. Results Compared with negative control group,the expressions of CaN mRNA and UⅡ RNA significantly declined at 21st day in JXG groups,which was lower in JXG high dose group than that in JXG low dose group(P<0.05).Compared with negative control group,the expressions of CaN mRNA and UⅡ RNA significantly declined at 35th day in JXG groups and perindopril group,which was lower in JXG groups than that in perindopril group,and was lower in JXG high dose group than that in JXG low dose group(P<0.05). Conclusion JXG can reduce the expressions of CaN mRNA and UⅡ RNA,and inhibit ventricular remodeling in SHR.
Keywords：chronic heart failureJianxin granulesspontaneously hypertensive ratscalcineurinurotensin Ⅱ
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 158-161 )