Clinical Study on Continuous Pumping of Torasemide and Isosorbide in the Treatment of Cardiorenal Syndrome
Tang Jin
Abstract：Objective To explore the effect of continuous pumping of torasemide and isoket (CPTAI)on cardiorenal syndrome (CRS). Methods Sixty-one patients with CRS were enrolled in this study.They were individed into the conventional treatment group(n=35)and the combined treatment group(n=26)according to whether using CPTAI or not.The vital signs,serum electrolyte,daily urine output and cardiorenal function were recorded.The left ventricular end-diastolic diameter (LVEDD),left ventricular posterior wal thickness (LVPW)and left ventricular ejection fraction (LVEF)were measured by color doppler echocardiography.The levels of ser-um angiotensin Ⅱ (Ang Ⅱ),aldosterone (ALD),norepinephrine (NE)and N-terminal pro brain natriuretic peptide (NT-proBNP) were measured.The readmission rate was fol owed up for one month.Results The total clinical effective rate was 69.2% in the com-bined treatment group,which was significantly higher than that in the conventional treatment group(42.8%,Pearsonχ2=4.1787,P<0.05).After treatment,the urine output was increased significantly in two groups.The diuretic effect was better in the combined treat-ment group.Compared with the conventional treatment group,the heart rate and the levels of serum AngⅡ,ALD,NT-proBNP were decreased while LVEF was increased in the combined treatment group(P<0.01).Conclusion CPTAI can quickly improve cardiore-nal function,attenuate water and sodium retention and electrolyte disorder,which may be related to the diuresis,vasodilation effect and neuroendocrine factors inhibition.
Keywords：cardiorenal syndrometorasemideisosorbideneuroendocrine factor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 82-85 )