Effects of Flupentixol and Melitracen on the Concentrations of Serum Adiponectin and Plasma BNP in Patients with Coronary Heart Disease related Heart Failure Complicated with Depression
Zhang Minli
Sun Jing
Zhu Ming
Wei Hongjie
Shi Junting
Jin Peng
Abstract：Objective To investigate the effects of flupentixol and melitracen (deanxit)on serum adiponectin (APN)and plasma B-type natriuretic peptide (BNP)in patients with coronary heart disease (CHD) related heart failure(HF)complicated with depression. Methods Sixty-two patients with CHD-related HF complicated with depression were randomly divided into two groups:control group (n=31)treated with routine treatment and psychological intervention,and treatment group (n=31)treated with flupentixol and melitracen in the basis of routine treatment and psychological intervention for 6 months. Hamilton Depression Rating Scale (HAMD)scores,6-minute walk test(6 mWT),the values of left ventricular end diastolic diameter(LVEDD)and left ventricular ejec-tion (LVEF),the levels of serum APN and plasma BNP were compared between two groups.Results Compared with the control group,HAMD scores was significantly improved in treatment group [(25.84± 5.88)vs (19.98± 6.29),P<0.05 ].6 mWT was signifi-cantly increased [(264.7± 31.4)m vs(331.4± 32.4)m,P<0.05 ].The value of LVEF was significantly enhanced in treatment group [(33.03± 6.34)% vs (36.87± 6.98)%,P<0.05 ].The level of serum APN was significantly increased in treatment group [(89.66± 21.37)ng/mL vs (102.78± 23.18)ng/mL,P<0.05].The level of plasma BNP was significantly decreased in treatment group [(467± 93)pg/mL vs (312± 83)pg/mL,P<0.05].There was no significant difference in the value of LVEDD between two groups.Conclusion Antidepressant treatment for 6 months can relieve the symptom of depression,improve the heart function,increase the level of ser-um APN and decrease the level of plasma BNP in patients with CHD-related HF complicated with depression.
Keywords：coronary heart diseaseheart failuredepressionadiponectinB-type natriuretic peptidedeanxit
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 66-69 )