Clinical Observation on Duloxetine in the Treatment of Orthostatic Hypotension with Anxiety and Depression
Wang Wenting
Qiu Fucheng
Dong Ci
Han Rui
Liu Huimiao
Xie Bingchuan
Zhang Lina
Zhang Zhenqing
Gu Ping
Abstract：Objective To investigate the efficacy and security of duloxetine in the treatment of orthostatic hypotension with anxiety and depression.Methods Thirty patients with orthostatic hypotension in the First Hospital of Hebei Medical University from March 2013 to March 2015 were screened.Sixteen patients with anxiety and depression were treated with duloxetine,and 14 cases were treated with midodrine hydrochloride.The drug efficacy was evaluated by the times of dizziness or syncope occurred within one week,orthostatic blood pressure changes,sympathetic skin response(SSR),the changes of Hamilton Anxiety Rating Scale (HAMA14)and Hamilton Depression Rating Scale (HAMD)24 before and 2 weeks,8 weeks after treatment.Treatment Emergent Symptom Scale(TESS)was used to evaluate the drug safety.Results Drug efficacy evaluation showed that the weekly occurrence times of dizziness and synco-pe were significantly decreased after treatment in two groups(P<0.001).At the 8nd weekend after treatment,the weekly occurrence times of dizziness and syncope in duloxetine group was obviously lower than that in midodrine group[(2.05±1.98)times/week vs (6.28± 2.15)times/week,t=5. 609,P<0. 001]. Orthostatic hypotension showed that the systolic and diastolic blood pressure were de-creased after treatment in two groups(P<0.01).The SSR showed that the latency were shorter and the amplitude were higher in two groups compared with before treatment(P<0.05).The scores of HAMA14 and HAMD24 were significantly decreased in duloxetine group compared with before treatment(F=297.57,180.16,P<0.001).There was no significant difference in the levels of the inci-dence of adverse drug reactions between two groups (P>0.05).Conclusion Duloxetine can improve the anxiety and depression of patients with orthostatic hypotension,relieve dizziness and syncope caused by orthostatic hypotension,promote autonomic nerve function,especial y applicable to the orthostatic hypotension patients complicated with anxiety and depression.
Keywords：orthostatic hypotensionduloxetinemidodrine hydrochlorideanxietydepression
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 21-25 )