Correlation of Serum Homocysteine Level with the Severity of Neurological Deficit in Patients with Ischemic Stroke
Jiang Zhihong
Ma Qiang
Liu Wenbo
Abstract：Objective To investigate the correlation of serum homocysteine level with the severity of neurological deficit in patients with cerebral infarction. Methods Sixty patients with cerebral infarction were selected in October 2013 to October 2015. Sixty healthy indi-viduals were as controls.The serum homocysteine level was detected by luminescence immunoassay. The correlation of serum homo-cysteine level with the severity of cerebral infarction was analyzed by multivariate analysis.Results Serum Hcy level was positively correlated with creatinine levels (t=2.734,P=2.734). There was significant difference in serum Hcy levels between cerebral infarc-tion patients with cardiogenic stroke(CS),large artery atherosclerosis (LAA),other etiologies (OE)and healthy control group (t=6.553,P=0.003;t=15.953,P=0.000,t=5.697,P=0.000). Serum Hcy levels in patients with hypoperfusion/impaired emboli clearance,carrier artery embolism perforators,arteries artery embolism and mixing mechanism were higher than that in healthy controls (t=5.215,P=0.003;t=11.918,P=0.000;t=6.066,P=0.000;t=4.016,P=0.028). There was significant difference in serum Hcy levels among different degree of severity (F=13.485,P=13.485). Serum Hcy level was positively correlated with the severity of cerebral infarction (r=0.708). Conclusion Serum Hcy level was positively correlated with the severity of cerebral infarc-tion.
Keywords：cerebral infarctionhomocysteineseverityhypoperfusionembobi clearancecarrierartery embolism perfooators
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2946-2949 )