Renal Protective Effect of Yanggan Yishui Granule in Spontaneously Hypertensive Rats
Zhang Yexiang
Zhou Yixuan
Hu Yebin
He Jia
Abstract：Objective To investigate the effect of Yanggan Yishui granule (YYG)on the levels of blood pressure,urinary microalbumin-uria (MA)in urine,kidney tissue endothelin 1 (ET 1),nitricoxide (NO),von Wil ebrand factor(vWF)in spontaneously hyperten-sive rats (SHR),and its mechanism of renal protection of SHR. Methods SHR were randomly divided into YYG group,captopril group,model group,8 each group.Eight Wistar Kyoto rats were as normal control group.After 6 weeks,the blood pressure,urinary MA,ET 1 in the kidney tissue,the expression of nitric oxide (NO)and vWF were tested. Results The blood pressure trend of progressive increase reduced in YYG group.Urinary MA was lower than that in model group after treatment (P<. 01).Compared with model group,the expressions of kidney tissue ET 1,vWF decreased significantly in YYG group(P<0.01).NO concentration signifi-cantly increased compared with model group (P< 0.01). Conclusion YYG has renal protective effect,which can reduce increased blood pressure,lower blood pressure,reduce the levels of urine MA,decrease the expressions of ET 1 and vWF in renal tissue, increase the levels of NO in SHR.
Keywords：spontaneous hypertension ratsYanggan Yishui granuleblood pressureurinary microalbuminuriaendothelinnitricoxidevon Wil ebrand factor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2891-2893 )