Protection of Tianma Shuxin Granule on Left Ventricular Diastolic Dysfunction in Spontaneous Hypertensive Rats
Pan Limin
Wang Yang
Liu Kun
Yin Yijian
Xu Guicheng
Abstract：Objective To investigate the effects of Tianma Shuxin granule (TSG)on blood pressure (BP)and left ventricular diastolic dysfunction in spontaneous hypertensive rats (SHR).Methods Fifty SHR were randomly divided into five groups:TSG groups (low dosage,medium dosage and high dosage group)treated with TSG extract,positive control group and model group treated with losartan potassium tablets suspension and distil ed water,respectively. The systolic caudal arterial pressure and heart rate were measured.After 18 weeks,the left ventricular end diastolic pressure (LVEDP),maximal rate of the decrease of left ventricular pres-sure(-dp/dtmax)were measured. Results Compared with the model group,the blood pressure was decreased significantly in al treated groups(P<0.01),but the heart rate had no difference. In model control group,LVEDP increased significantly (P<0.01), dp/dtmax absolute value decreased significantly (P<0.01). But the LVEDP was decreased,-dp/dtmax absolute value was raised in the positive control group and TSG groups,and there was a significant difference compared with the model group (P<0.05 or P<0.01).Conclusion Left ventricular diastolic dysfunction in SHR was characterized as the LVEDP increased,the absolute value of dp/dt-max decreased. TSG had markedly effect in lowering blood pressure,improving the left ventricular dysfunction in SHR.
Keywords：hypertensionTianma Shuxin granuleleft ventricular diastolic dysfunctionspontaneous hypertensive ratstraditional Chi-nese medicine
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2887-2890 )